Raghavan Laboratory MSII Room 6711
Human leukocyte antigen (HLA) class I molecules bind to intracellular peptides and present these peptides to cytotoxic T cells, which recognize and kill virus-infected cells and tumor cells. HLA class I molecules also regulate the functional activities of natural killer (NK) cells of the immune response. Our laboratory studies the assembly pathways of major histocompatibility complex (MHC) class I molecules. The HLA class I genes are among the most polymorphic of human genes, and these genes were determinants of life and death prior to the availability of modern medical interventions. We study how genetic variations in HLA class I affect the biology of HLA class I assembly in the cell, and the resulting influences upon disease outcomes. We also study mechanisms of protein folding in the endoplasmic reticulum (ER) of cells, and their dysregulation in disease. A better understanding of these fundamental cellular and molecular processes will allow more targeted approaches to treatments of infectious diseases, cancers and protein misfolding diseases.
"Strong environmental, health and safety management (EHS) is critical to all laboratory research, including our own. Now, more than ever, it is important to do what we can to conserve energy and protect the environment. Many small changes in laboratory practices can have a large impact on the environment. For example, the use of Gel Red instead of Ethidium Bromide improves environmental safety. By joining the Sustainable Lab program, our laboratory has increased awareness about the most environmentally healthy and safe lab practices, which will help towards the preservation and sustenance of our planet for future generations." - Stephanie Mrowczynski
Richardson/Somers Laboratory BSRB Room 3220
The research in our lab focuses on the immunology and epigenetics of autoimmune disease with special attention on lupus. Techniques are biologic based and include working with human and animal tissues, in vitro culture, PCR, Western blots, and ELISA’s. Equipment and techniques performed are in accordance with these assays. Waste generated from our is disposed of following EHS guidelines.
“We were not aware of the large implications on recycling and energy conservation that small changes in a lab can have big impact on the environment, such as choosing environmentally-friendly alternatives to dyes and recycling, until joining the Sustainable Lab program. Now more than ever it is important to do what we can to conserve energy and protect the environment, and this program allows our lab to do both on a daily basis”. Dr. Faith Strickland, Lab Manager
Cohen Laboratory NCRC Bldg. 20 Room 326-05W
Our research focuses on the translational targeted cancer-drug development and drug delivery systems in Thyroid cancer, head and neck squamous cell cancer, melanoma and breast cancer. Our clinical interests include endocrine surgery specifically thyroid surgery for benign and malignant disease, minimally invasive parathyroid surgery and adrenalectomy, as well as surgery for advanced melanomas including hyperthermic isolated limb perfusion. We employ molecular biology and cell culture techniques and waste generated is disposed of adhering to U-M EHS guidelines.
This program allowed us to address on small changes to bring big impact on the environment, such as energy conservation, recycling and many other initiatives. Now more than ever it is important to do what we can to conserve energy and protect the environment, and this program allows our lab to do both on a daily basis. We recommend it to every lab on our campus Dr. Chitra Subramanian, Lab Manager
Dauer Laboratory BSRB Room 4138
The central goal of our studies is to unravel the molecular and cellular mechanisms of diseases that disrupt the motor system. In exploring these diseases, we are also interested in understanding a fundamental question relevant to CNS disease generally: what factors determine the selective vulnerability of particular cell types or circuits to particular insults? Our primary focus is on Parkinson’s disease and DYT1 dystonia. For each of these projects, we focus our efforts on disease genes that cause these disorders, employing a range of molecular, cellular, and whole animal studies to dissect the normal role of disease proteins, and how pathogenic mutations lead to disease.
I was not aware of the large implications that many small changes in a lab can have on the environment, such as increasing our -80 degree freezer to -70 degrees, until joining the Sustainable Lab program. Now more than ever it is important to do what we can to conserve energy and protect the environment, and this program allows our lab to do both on a daily basis. Stephanie Mrowczynski, Technician
Vittal Laboratory BSRB Room 4858
Our research focuses on the mechanisms underlying immune-mediated lung injury with emphasis on understanding epithelial injury and mesenchymal activation in Idiopathic Pulmonary Fibrosis (IPF) and chronic rejection occurring post-lung transplantation. IPF is the most common form on interstitial lung diseases (ILD) with an ‘orphan disease” status. It has no known etiology or an effective treatment modality that can reverse the progression of the disease. Our work focuses on the roles of IL-17A in epithelial injury and mesenchymal activation and complement activation in epithelial injury and tissue repair. We employ techniques like cell culture, QPCR, Western blot, Fluorescent staining and micro biology protocols. The solid and hazardous waste generated from our lab is being disposed of adhering to U-M EHS guidelines.
“The Vittal lab is glad to participate in the Sustainable Lab program, which helps our lab take steps towards creating a safe eco-friendly laboratory environment.” -- Ellyse Cipolla, Lab Manager
Keller Laboratory NCRC Bld 20 Room 326W-2 to 4
Our lab investigates mechanisms that contribute to bone metastasis of prostate cancer. We also have active interest in the contribution of aging to the development of genitourinary disease, and employ several animal models (including zebrafish) to pursue these studies. The solid and hazardous waste generated from our lab is being disposed of in adherence to U-M EHS guidelines.
“We are happy to participate in the Sustainable Lab program, and we have taken steps to create a safer and more sustainable laboratory environment. We recycle waste when appropriate, purchase eco-friendly products, and turn off and unplug unused devices to reduce energy consumption. By participating in various campus reuse programs, we try to re-use reagents, materials, and equipment before purchasing new ones. We are glad to contribute to U-M’s campus-wide goals to improve up on sustainability” -- June Escara-Wilke, Greg Shelley: Lab Managers
Lin Laboratory NCRC Bld. 28 Room G097E
Our work specializes in the study of microbial consortia. As a result, we do considerable genetic work, including various standard biological procedures that include but are not limited to PCR, gel electrophoresis, genetic transformations, HPLC and fluorescent microscopy. We also use various microfluidic techniques to study microbial communities in droplets for high throughput applications. Hazardous and non-hazardous waste generated in our lab is disposed of adhering to U-M EHS guidelines.
“Functionalized sustainability initiatives demand a shared vision as no single actor is capable of building a sustainable enterprise. Instead, they necessitate making our collective diversity work for us rather than against us. The sustainable lab program facilitates this work by enabling members from across the research community to make conscious behavioral changes that reduce waste and ultimately promote sustainable laboratory practices.”
David Carruthers, Sustainability Liaison
Fenno Laboratory Dental Institute Rooms 3204 & 3205
Research in our lab focuses on the role of the oral spirochete Treponema denticola in the development of periodontal diseases. The studies involve molecular characterization of spirochete surface-expressed and secreted proteins and their interactions with host tissue components. These studies, which involve both genetic and biochemical analyses, will contribute to the understanding of microbe-host interactions in the etiology of periodontal diseases, as well as to basic knowledge of the molecular biology of pathogenic spirochetes. Waste generated in our lab is disposed of adhering to EHS guidelines.
“With the help of the Sustainable Lab program staff, our wet lab space has taken many steps to create a safer and more sustainable laboratory environment. We recycle waste when appropriate, purchase eco-friendly products, and turn off and unplug unused devices to reduce our energy consumption. By utilizing the Chemical Reuse program, we try to first implement used materials before purchasing new ones. It is a pleasure to participate in this program to help U-M reach its campus-wide sustainability goals” -- Paula Goetting, Lab Manager
Hodgin Laboratory MSRB I Room A526
Our research interests include creating and maintain a Digital Pathology Image Repository for renal diseases and mouse models of glomerular injury, with a focus on podocyte biology. We employ various computational techniques to analyze damage to specific portions of the kidney. To investigate the key pathogenic mechanisms of mouse disease models, we are employing systems biology approaches to identify cross-species, human-mouse shared transcriptional networks. We employ techniques such as PCR, IHC, IF protocols, Western blots etc., Solid and hazardous waste generated in our lab in disposed of following EHS guidelines.
“With the help of the Sustainable Lab program staff, our wet lab space has taken many steps to create a safer and more sustainable laboratory environment. We have eliminated ethidium bromide and use the SYBR Safe gel dye alternative, recycle waste when appropriate, purchase eco-friendly products, and turn off and unplug unused devices to reduce our energy consumption. By utilizing the Chemical Reuse program, we try to first implement used materials before purchasing new ones. It is a pleasure to participate in this program to help U-M reach its campus-wide sustainability goals”
-- Stephanie Wylie, Lab Manager
Molecular Micro Laboratory University Hospital South Rms: F2541, F2500, F2505
Our lab performs clinical operations for the Michigan Medical facility. We perform PCR testing and employ the following equipment: Hologic Panther, Roche Cobas X4800, Focus Integrated Cyclers, Abbott m2000sp and m2000rt and Eli Tech.
“Being enrolled in the Sustainable Laboratory program has given us the opportunity to lessen our carbon footprint as we can reduce our waste, save money on electricity, and disposal of harmful reagents into the environment. We no longer use ethidium bromide, and also use the Chemical Reuse program.” -- AJ Dudus, Medical Technologist